Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital
Scope of duties
The overall goal of our interdisciplinary and international research group is to explore molecular causes in
children with life-threatening very early onset inflammatory bowel disease (VEO-IBD). In particular, our
laboratory focuses on decoding genetic and immune signatures of VEO-IBD by employing omics-based
technologies and advanced preclinical models. Our studies will lead to new insights into disease pathogenesis,
diagnosis, and treatment for children with this intractable disease.
Our laboratory is affiliated at the CCRC Hauner (http://www.ccrc-hauner.de) that has an outstanding track record
in translational sciences and is fully equipped with state-of-the-art laboratory instrumentation and core
facilities (e.g., NGS, flow cytometry, confocal microscopy, bioinformatics, mass spectrometry, computational
biology). Our institute follows the mission “Concept Pediatrics – the Child at the Center of Science”
exemplifying the interaction of molecular research with patient-oriented clinical applications.
For a DFG-funded project of the TRR338 “LETSimmun” (Lymphocyte Engineering for Therapeutic Synthetic
Immunity), the research group “Mucosal Immunology” headed by Dr. Daniel Kotlarz at the Comprehensive
Childhood Research Center of the Dr. von Hauner Children’s Hospital (CCRC Hauner) is now offering a position
for a highly motivated PhD student.
The successful candidate will evaluate innovative non-viral CRISPR/Cas9-mediated genome targeting
approaches for the correction of human T cell dysfunctions associated with VEO-IBD in humanized mouse
models. The candidate will be introduced into our innovative and advanced experimental pipeline of human
disease models including CRISPR/Cas9-mediated genome editing, induced pluripotent stem cells, and
humanized mouse models. The project is integrated in the DFG-funded TRR338 (https://letsimmun.de) and
successful candidates will benefit from the IRTG graduate program.
– You are highly motivated and share our enthusiasm for translational science
– You want to help pediatric patients by dissecting disease mechanisms of inflammatory bowel disease
– You are a team player
– You have completed or will soon complete a qualifying degree (Master, Diploma, or similar) in medicine,
veterinary medicine, life sciences, pharmacy, or a related discipline
– You have first experience in basic techniques of biochemistry, cellular biology, and molecular biology
– You are flexible and proactive person with strong interpersonal skills
The position is initially for 2 years and the remuneration is based on the Collective Agreement for the
Public Sector of the Länder (TV-L) including all allowances customary in the public sector.
A dynamic, highly motivated, and international team in a research environment at one of Germany’s top
Well-funded and -equipped lab with excellent core facility support
Documented expertise in immunological, molecular and cell biological and genetic experimental techniques
Established state-of-the art experimental pipeline with mentoring by advanced researchers
Integration in strong international alliances and networks with worldwide leading research institutes
More information: download pdf
Please use the Online-Form for your application
David Illig: 089 4400 57985