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Kruse, B., Buzzai, A. C., Shridhar, N., Braun, A. D., Gellert, S., Knauth, K., Pozniak, J., Peters, J., Dittmann, P., Mengoni, M., van der Sluis, T. C., Höhn, S., Antoranz, A., Krone, A., Fu, Y., Yu, D., Essand, M., Geffers, R., Mougiakakos, D., Kahlfuß, S., …, Kastenmüller, W.,… Tüting, T. (2023). CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours. Nature, 10.1038/s41586-023-06199-x. Advance online publication. https://doi.org/10.1038/s41586-023-06199-x (B06)

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Nixdorf, D., Sponheimer, M., Berghammer, D., Engert, F., Bader, U., Philipp, N., Kazerani, M., Straub, T., Rohrbacher, L., Wange, L., Dapa, S., Atar, D., Seitz, C. M., Brandstetter, K., Linder, A., von Bergwelt, M., Leonhardt, H., Mittelstaet, J., Kaiser, A., Bücklein, V., … Subklewe, M. (2023). Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML. Leukemia, 37(6), 1298–1310. https://doi.org/10.1038/s41375-023-01905-0 (B01)

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Dötsch, S., Svec, M., Schober, K., Hammel, M., Wanisch, A., Gökmen, F., Jarosch, S., Warmuth, L., Barton, J., Cicin-Sain, L., D’Ippolito, E., & Busch, D. H. (2023). Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression. Proceedings of the National Academy of Sciences of the United States of America, 120(10), e2200626120. https://doi.org/10.1073/pnas.2200626120 (A01)

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Rejeski, K., Cordas Dos Santos, D. M., Parker, N. H., Bücklein, V. L., Winkelmann, M., Jhaveri, K. S., Liu, L., Trinkner, P., Günther, S., Karschnia, P., Blumenberg, V., Schmidt, C., Kunz, W. G., von Bergwelt-Baildon, M., Jain, M. D., Theurich, S., & Subklewe, M. (2023). Influence of Adipose Tissue Distribution, Sarcopenia, and Nutritional Status on Clinical Outcomes After CD19 CAR T-cell Therapy. Cancer immunology research, 11(6), 707–719. https://doi.org/10.1158/2326-6066.CIR-22-0487 (B01, C05)

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Kuhl, N., Linder, A., Philipp, N., Nixdorf, D., Fischer, H., Veth, S., Kuut, G., Xu, T. T., Theurich, S., Carell, T., Subklewe, M., & Hornung, V. (2023). STING agonism turns human T cells into interferon-producing cells but impedes their functionality. EMBO reports, 24(3), e55536. https://doi.org/10.15252/embr.202255536 (B01, C03, C05)

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Pachmayr, L. O., Muehlbauer, A., Flommersfeld, S., Graml, F., Hoenninger, J., von Baumgarten, L., Buchholz, V. R., & Grassmann, S. (2023). Unbiased chemokine receptor screening reveals similar efficacy of lymph node- and tumor-targeted T cell immunotherapy. Cancer immunology, immunotherapy : CII, 10.1007/s00262-023-03472-w. Advance online publication. https://doi.org/10.1007/s00262-023-03472-w (B02)

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Seifert, M., Benmebarek, M. R., Briukhovetska, D., Märkl, F., Dörr, J., Cadilha, B. L., Jobst, J., Stock, S., Andreu-Sanz, D., Lorenzini, T., Grünmeier, R., Oner, A., Obeck, H., Majed, L., Dhoqina, D., Feinendegen, M., Gottschlich, A., Zhang, J., Schindler, U., Endres, S., … Kobold, S. (2022). Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function. British journal of cancer, 127(12), 2175–2185. https://doi.org/10.1038/s41416-022-02013-z (B01)

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Mateyka, L. M., Strobl, P. M., Jarosch, S., Scheu, S. J. C., Busch, D. H., & D’Ippolito, E. (2022). Gene Signatures of T-Cell Activation Can Serve as Predictors of Functionality for SARS-CoV-2-Specific T-Cell Receptors. Vaccines, 10(10), 1617. https://doi.org/10.3390/vaccines10101617 (A01)

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Groll, T., Silva, M., Sarker, R. S. J., Tschurtschenthaler, M., Schnalzger, T., Mogler, C., Denk, D., Schölch, S., Schraml, B. U., Ruland, J., Rad, R., Saur, D., Weichert, W., Jesinghaus, M., Matiasek, K., & Steiger, K. (2022). Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression. Cancers, 14(9), 2248. https://doi.org/10.3390/cancers14092248 (C01)

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Dos Santos, D. M. C., Rejeski, K., Winkelmann, M., Liu, L., Trinkner, P., Günther, S., Bücklein, V. L., Blumenberg, V., Schmidt, C., Kunz, W. G., Von Bergwelt-Baildon, M., Theurich, S., & Subklewe, M. (2022). Increased visceral fat distribution and body composition impact cytokine release syndrome onset and severity after CD19 chimeric antigen receptor T-cell therapy in advanced B-cell malignancies. Haematologica, 107(9), 2096–2107. https://doi.org/10.3324/haematol.2021.280189 (B01, C05)

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Gosmann, D., Russelli, L., Weber, W. A., Schwaiger, M., Krackhardt, A. M., & D’Alessandria, C. (2022). Promise and challenges of clinical non-invasive T-cell tracking in the era of cancer immunotherapy. EJNMMI research, 12(1), 5. https://doi.org/10.1186/s13550-022-00877-z (A03)

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Kaeuferle, T., Stief, T. A., Canzar, S., Kutlu, N. N., Willier, S., Stenger, D., Ferrada-Ernst, P., Habjan, N., Peters, A. E., Busch, D. H., & Feuchtinger, T. (2022). Genome-wide off-target analyses of CRISPR/Cas9-mediated T-cell receptor engineering in primary human T cells. Clinical & translational immunology, 11(1), e1372. https://doi.org/10.1002/cti2.1372 (A01, B04, Z03)

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Wagner, K. I., Mateyka, L. M., Jarosch, S., Grass, V., Weber, S., Schober, K., Hammel, M., Burrell, T., Kalali, B., Poppert, H., Beyer, H., Schambeck, S., Holdenrieder, S., Strötges-Achatz, A., Haselmann, V., Neumaier, M., Erber, J., Priller, A., Yazici, S., Roggendorf, H., Protzer, U… Busch, D. H. (2022). Recruitment of highly cytotoxic CD8+ T cell receptors in mild SARS-CoV-2 infection. Cell reports, 38(2), 110214. https://doi.org/10.1016/j.celrep.2021.110214 (A01, B07)

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Albanese, M., Ruhle, A., Mittermaier, J., Mejías-Pérez, E., Gapp, M., Linder, A., Schmacke, N. A., Hofmann, K., Hennrich, A. A., Levy, D. N., Humpe, A., Conzelmann, K. K., Hornung, V., Fackler, O. T., & Keppler, O. T. (2022). Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses. Nature methods, 19(1), 81–89. https://doi.org/10.1038/s41592-021-01328-8(C03

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Schreiber, S., Honz, M., Mamozai, W., Kurktschiev, P., Schiemann, M., Witter, K., Moore, E., Zielinski, C., Sette, A., Protzer, U., & Wisskirchen, K. (2021). Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors. Molecular therapy. Methods & clinical development, 23, 476–489. https://doi.org/10.1016/j.omtm.2021.10.012 (B07)

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Wu, H., Brand, B., Eckstein, M., Hochrein, S. M., Shumanska, M., Dudek, J., Nickel, A., Maack, C., Bogeski, I., & Vaeth, M. (2021). Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo. Frontiers in pharmacology, 12, 734078. https://doi.org/10.3389/fphar.2021.734078 (C05)

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Bashiri Dezfouli, A., Yazdi, M., Pockley, A. G., Khosravi, M., Kobold, S., Wagner, E., & Multhoff, G. (2021). NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development. Cells, 10(12), 3390. https://doi.org/10.3390/cells10123390 (B01)

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Zhang, W., Karschnia, P., von Mücke-Heim, I. A., Mulazzani, M., Zhou, X., Blobner, J., Mueller, N., Teske, N., Dede, S., Xu, T., Thon, N., Ishikawa-Ankerhold, H., Straube, A., Tonn, J. C., & von Baumgarten, L. (2021). In vivo two-photon characterization of tumor-associated macrophages and microglia (TAM/M) and CX3CR1 during different steps of brain metastasis formation from lung cancer. Neoplasia (New York, N.Y.), 23(11), 1089–1100. https://doi.org/10.1016/j.neo.2021.09.001 (B02)

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Altstetter, S. M., Quitt, O., Pinci, F., Hornung, V., Lucko, A. M., Wisskirchen, K., Jung, S., & Protzer, U. (2021). Hepatitis-D Virus Infection Is Not Impaired by Innate Immunity but Increases Cytotoxic T-Cell Activity. Cells, 10(11), 3253. https://doi.org/10.3390/cells10113253 (B07, C03)

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Bräunlein, E., Lupoli, G., Füchsl, F., Abualrous, E. T., de Andrade Krätzig, N., Gosmann, D., Wietbrock, L., Lange, S., Engleitner, T., Lan, H., Audehm, S., Effenberger, M., Boxberg, M., Steiger, K., Chang, Y., Yu, K., Atay, C., Bassermann, F., Weichert, W., Busch, D. H.,Krackhardt, A. M. (2021). Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma. Journal for immunotherapy of cancer, 9(9), e002754. https://doi.org/10.1136/jitc-2021-002754 (A01, A03)

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Müller, T. R., Jarosch, S., Hammel, M., Leube, J., Grassmann, S., Bernard, B., Effenberger, M., Andrä, I., Chaudhry, M. Z., Käuferle, T., Malo, A., Cicin-Sain, L., Steinberger, P., Feuchtinger, T., Protzer, U., Schumann, K., Neuenhahn, M., Schober, K., & Busch, D. H. (2021). Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. Cell reports. Medicine, 2(8), 100374. https://doi.org/10.1016/j.xcrm.2021.100374 (A01, B04, B07)

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Liebl K, Aschenbrenner I, Schiller L, Kerle A, Protzer U, Feige MJ. Modeling of the human interleukin 12:receptor complex allows to engineer attenuated cytokine variants. Mol Immunol. 2023 Oct;162:38-44. doi: 10.1016/j.molimm.2023.08.010. Epub 2023 Aug 26. PMID: 37639747.(A04, B07)

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Aschenbrenner I, Siebenmorgen T, Lopez A, Parr M, Ruckgaber P, Kerle A, Rührnößl F, Catici D, Haslbeck M, Frishman D, Sattler M, Zacharias M, Feige MJ. Assembly-dependent Structure Formation Shapes Human Interleukin-23 versus Interleukin-12 Secretion. J Mol Biol. 2023 Oct 5;435(23):168300. doi: 10.1016/j.jmb.2023.168300. Epub ahead of print. PMID: 37805067. (A04)

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Hildenbrand K, Bohnacker S, Menon PR, Kerle A, Prodjinotho UF, Hartung F, Strasser PC, Catici DAM, Rührnößl F, Haslbeck M, Schumann K, Müller SI, da Costa CP, Esser-von Bieren J, Feige MJ. Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions. Sci Adv. 2023 Oct 27;9(43):eadg6874. doi: 10.1126/sciadv.adg6874. Epub 2023 Oct 25. PMID: 37878703. (A04, C04)

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Tretter, C., de Andrade Krätzig, N., Pecoraro, M., Lange, S., Seifert, P., von Frankenberg, C., Untch, J., Zuleger, G., Wilhelm, M., Zolg, D. P., Dreyer, F. S., Bräunlein, E., Engleitner, T., Uhrig, S., Boxberg, M., Steiger, K., Slotta-Huspenina, J., Ochsenreither, S., von Bubnoff, N., Bauer, S., … Krackhardt, A. M. (2023). Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification. Nature communications, 14(1), 4632. https://doi.org/10.1038/s41467-023-39570-7 (A03)

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Schmidt H, Raj T, O’Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V. Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2309205120. doi: 10.1073/pnas.2309205120. Epub 2023 Nov 21. PMID: 37988467; PMCID: PMC10691344. (C01, C02)

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Pachmayr, L. O., Muehlbauer, A., Flommersfeld, S., Graml, F., Hoenninger, J., von Baumgarten, L., Buchholz, V. R., & Grassmann, S. (2023). Unbiased chemokine receptor screening reveals similar efficacy of lymph node- and tumor-targeted T cell immunotherapy. Cancer immunology, immunotherapy : CII, 72(9), 3111–3124. https://doi.org/10.1007/s00262-023-03472-w

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Wu, H., Zhao, X., Hochrein, S. M., Eckstein, M., Gubert, G. F., Knöpper, K., Mansilla, A. M., Öner, A., Doucet-Ladevèze, R., Schmitz, W., Ghesquière, B., Theurich, S., Dudek, J., Gasteiger, G., Zernecke, A., Kobold, S., Kastenmüller, W., & Vaeth, M. (2023). Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming. Nature communications, 14(1), 6858. https://doi.org/10.1038/s41467-023-42634-3

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Dr. Magdalena Nauerth

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+4989 4140 6887

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