Prof. Dr. med. Sebastian Theurich
Medizinische Klinik und Poliklinik III
Klinikum der Ludwig-Maximilians-Universität München
Marchioninistr. 15
81377 München
and
Genzentrum
Ludwig-Maximilians-Universität München
Feodor-Lynen-Str. 25
81377 München
Phone: +49 (0)89-4400-53405
Email: Sebastian.theurich@med.uni-muenchen.de
University training and degree
1997 – 2004 Medical School, Universities of Lübeck, Berlin and Umea (Sweden)
2001 Clinical Fellowship, Columbia University, New York, USA
2004 Approbation in Medicine (with honours), Charité, Humboldt University Berlin
Advanced academic qualifications
02/2020 Professor of Medicine (W2, Cancer and Immunometabolism), LMU Munich
2018 Certified Specialist for Hematopoietic Stem Cell Transplantation (DAG-KMT)
2018 Certified Specialist for Clinical Nutrition (DGEM, DAEM)
2015 Habilitation for Internal Medicine, Medical Faculty, University of Cologne, (Mentor: Prof. Dr. Michael Hallek, Director Department of Medicine I, University Hospital of Cologne)
2012 Board Certification for Internal Medicine, Hematology and Oncology
2006 Doctorate (summa cum laude), (Supervisor: Prof. Dr. B. Dörken), Max-Delbrück Center for Molecular Medicine Berlin-Buch and Charité Berlin
2007 Certified physician for clinical trials (Prüfarzt) and LKP (2018)
Postgraduate professional career
Since 2019 Head of the Cancer- and Immunometabolism Research Group, Gene Center LMU, Munich
Since 2019 Head of the Interdisciplinary Oncologic Outpatient Unit, Campus Innenstadt, Dpt. Medicine III, LMU University Hospital
07/2018 Attending Physician and Interim-Professorship, Department of Medicine III, University Hospital Munich, LMU
2017 Independent Junior Research Group Leader, Department I of Internal Medicine, University Hospital of Cologne
2013 – 2016 Postdoctoral Research Fellowship, Max-Planck-Institute for Metabolism Research (Prof. Jens C. Brüning), Cologne
2009 – 2012 Resident, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany (Prof. M. Hallek)
2006 – 2009 Resident, Dpt. of Internal Medicine IV, Martin-Luther-University Halle-Wittenberg, Halle, Germany (Prof. H.J. Schmoll)
2004 – 2006 Resident, Hematology & Tumorimmunology, Charité Berlin, Germany (Prof. B. Dörken, Prof. W.D. Ludwig)
2019 Researcher of the German Cancer Consortium (DKTK), Munich Site
2018 Member of the Editorial Board, “Immunometabolism”
2018 Basic Science Research Award 2018, Glaxo-Smith-Kline Foundation
2015 Scientific Secretary for the Annual Congress of the German Society for Internal Medicine 2015 (Congress President: Prof. M. Hallek)
Since 2012 Associate Editor of Cochrane Haematology
2013 – 2015 Clinician Scientist Scholarship, (DFG and Medical Faculty, University of Cologne
2002 Erasmus Study Scholarship, (EU)
1996 – 2004 Study Scholarship, Ev. Studienwerk Villigst, Germany
a) Articles published by outlets with scientific quality assurance, book publications and works accepted for publication, but not yet published
1. Fürstenau M, Hopfinger G, Robrecht S, Fink AM, Al-Sawaf O, Langerbeins P, Cramer P, Tresckow JV, Maurer C, Kutsch N, Hoechstetter M, Dreyling M, Lange E, Kneba M, Stilgenbauer S, Döhner H, Hensel M, Kiehl MG, Jaeger U, Wendtner CM, Goede V, Fischer K, von Bergwelt-Baildon M, Eichhorst B, Hallek M, Theurich S. Influence of obesity and gender on treatment outcomes in patients with chronic lymphocytic leukemia (CLL) undergoing rituximab-based chemoimmunotherapy. Leukemia. 2020 Apr;34(4):1177-1181. doi: 10.1038/s41375-019-0630-6 . Epub 2019 Nov 14. PMID: 31728057
2. Wunderlich CM, Ackermann PJ, Ostermann AL, Adams-Quack P, Vogt MC, Tran ML, Nikolajev A, Waisman A, Garbers C, Theurich S, Mauer J, Hövelmeyer N, Wunderlich FT. Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nature Communications, 2018 Apr 25;9(1):1646. doi: 10.1038/s41467-018-03773-0 . PMID: 29695802
3. Theurich S, Tsaousidou E, Hanssen R, Lempradl AM, Mauer J, Timper K, Schilbach K, Folz-Donahue K, Heilinger C, Sexl V, Pospisilik JA, Wunderlich FT, Brüning JC. IL-6/Stat3-Dependent Induction of Distinct, Obesity-Associated Natural Killer Cells Deteriorates Energy and Glucose Homeostasis. Cell Metabolism, 2017 Jul 5;26(1):171-184.e6. doi: 10.1016/j.cmet.2017.05.018 . PMID: 28683285
4. Xu E, Pereira MMA, Karakasilioti I, Theurich S, Al-Maarri M, Rappl G, Waisman A, Wunderlich FT, Brüning JC. Temporal and tissue-specific requirements for T-lymphocyte IL-6 signaling in obesity-associated inflammation and insulin resistance, Nature Communications, 2017 May 3;8:14803. doi: 10.1038/ncomms14803 . PMID: 28466852
5. Theurich S, Rothschild SI, Hoffmann M, Fabri M, Sommer A, Garcia-Marquez M, Thelen M, Schill C; Merki R, Schmid T, Koeberle D, Zippelius A, Baues C, Mauch C, Tigges C, Kreuter A, Borggrefe J, von Bergwelt-Baildon M, Schlaak M. Local Tumor Treatment in Combination with Systemic Ipilimumab Immunotherapy Prolongs Overall Survival in Patients with Advanced Malignant Melanoma. Cancer Immunology Research, 2016 Sep 2;4(9):744-54. doi: 10.1158/2326-6066.CIR-15-0156 . Epub 2016 Jul 27. PMID: 27466265
6. Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell, 2016 May 5;165(4):882-95. doi: 10.1016/j.cell.2016.03.033 . Epub 2016 Apr 28. PMID: 27133169
7. Wensveen FM, Jelencic V, Valentić S, Šestan M, Turk Wensveen T, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O and Polić B. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nature Immunology, 2015 Apr;16(4):376-85. doi: 10.1038/ni.3120 . Epub 2015 Mar 2. PMID: 25729921
8. Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel LP. Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia. 2015 Apr;29(4):981-4. doi: 10.1038/leu.2014.320 . Epub 2014 Nov 7. PMID: 25376373
9. Theurich S, Schlaak M, Steguweit H, Heukamp LC, Wennhold K, Kurschat P, et al. Targeting Tumor-Infiltrating B Cells in Cutaneous T-Cell Lymphoma. Journal of Clinical Oncology, 2016 Apr 20;34(12):e110-6. doi: 10.1200/JCO.2013.50.9471. Epub 2014 Oct 27. PMID: 25348001
10. Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nature Immunology. 2014 May;15(5):423-30. doi: 10.1038/ni.2865 . Epub 2014 Mar 30. PMID: 24681566