Prof. Dr. med. Dirk H. Busch

Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (MIH)

Technische Universität München
Trogerstr. 30
81675 München
Phone: +49 89 4140 4120
Email: dirk.busch@tum.de

University training and degree

Medicine Universität Mainz (1987 – 1992), Universität Freiburg (1992 – 1993), Dr. med. (1987 – 1993)

Advanced academic qualifications

2001 Habilitation: Microbiology and Immunology, TU München, Mentor: Hermann Wagner
1993
Dissertation: Endocrinology, Universität Mainz, Mentor: Jürgen Schrezenmeir

Postgraduate professional career

Since 2009 Director, TU München, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
1999 – 2008
Groupleader, TU München, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
1996 – 1999
Postdoc, group of Eric Pamer, Yale University, New Haven/USA
1995 – 1996
Postdoc, Universitätsklinik Würzburg, Laboratory of Pediatric Rheumatology and Clinical Immunology

Since 2019 Deputy Chair DZIF
2017
Elected member of the National Academy of Sciences Leopoldina
2015
Visiting Scientist Award of the Australasian Society for Immunology
2010
Member of the Institute of Advanced Study (IAS) at TUM
2008
Science Day Award, Helmholtz Zentrum München
2003
Wilhelm Vaillant Prize, Munich
2002
Hans Krebs Prize, Hannover
2002
Robert Koch Postdoc Award
2000
Gerhard Hess Research Award from DFG
1999
Howard Hughes Medical Institute Postdoc Fellowsh

a) Articles published by outlets with scientific quality assurance, book publications and works accepted for publication, but not yet published

1. Schober, K.*, Voit, F.*, Grassmann, S., Muller, T.R., Eggert, J., Jarosch, S.,Weisbrich, B.,Hoffmann, P., Borkner, L., Nio, E., Fanchi, L., Clouser, C.R.,Radhakrishnan, A., Mihatsch, L.,Luckemeier, P., Leube, J., Dossinger, G., Klein, L.,Neuenhahn, M., Oduro, J.D., Cicin-Sain, L.,Buchholz, V.R., Busch, D.H. Dominant low affinity clonotypes arise from reverse TCR repertoire evolution during chronic CMV infection. Nat. Immunol. doi: 10.1038/s41590-020-0628-2

2. Schober, K., Muller, T.R., Gokmen, F., Grassmann, S., Effenberger, M., Poltorak, M., Stemberger, C., Schumann, K., Roth, T.L., Marson, A., and Busch, D.H. (2019). Orthotopic replacement of T-cell receptor alpha- and beta-chains with preservation of near-physiological T-cell function. Nat Biomed Eng. doi:10.1038/s41551-019-0409-0

3. Neuenhahn M, Albrecht J, Odendahl M, Schlott F, Dossinger G, Schiemann M, Lakshmipathi S, Martin K, Bunjes D, Harsdorf S, Weissinger EM, Menzel H, Verbeek M, Uharek L, Kroger N, Wagner E, Kobbe G, Schroeder T, Schmitt M, Held G, Herr W, Germeroth L, Bonig H, Tonn T, Einsele H, Busch DH*, Grigoleit GU*. Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT. Leukemia 2017. *contributed equally

4. Paszkiewicz PJ, Frassle SP, Srivastava S, Sommermeyer D, Hudecek M, Drexler I, Sadelain M, Liu L, Jensen MC, Riddell SR, Busch DH. Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia. J Clin Invest 2016;126:4262-4272.

5. Stemberger C, Graef P, Odendahl M, Albrecht J, Dossinger G, Anderl F, Buchholz VR, Gasteiger G, Schiemann M, Grigoleit GU, Schuster FR, Borkhardt A, Versluys B, Tonn T, Seifried E, Einsele H, Germeroth L, Busch DH*, Neuenhahn M*. Lowest numbers of primary CD8(+) T cells can reconstitute protective immunity upon adoptive immunotherapy. Blood 2014;124:628-37. *contributed equally

6. Graef P, Buchholz VR, Stemberger C, Flossdorf M, Henkel L, Schiemann M, Drexler I, Hofer T, Riddell SR, Busch DH. Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells. Immunity 2014;41:116-26.

7. Nauerth M, Weissbrich B, Knall R, Franz T, Dossinger G, Bet J, Paszkiewicz PJ, Pfeifer L, Bunse M, Uckert W, Holtappels R, Gillert-Marien D, Neuenhahn M, Krackhardt A, Reddehase MJ, Riddell SR, Busch DH. TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer. Sci Transl Med 2013;5:192ra87.

8. Buchholz VR, Flossdorf M, Hensel I, Kretschmer L, Weissbrich B, Graf P, Verschoor A, Schiemann M, Hofer T, Busch DH. Disparate individual fates compose robust CD8+ T cell immunity. Science 2013;340:630-5.

9. Verschoor A, Neuenhahn M, Navarini AA, Graef P, Plaumann A, Seidlmeier A, Nieswandt B, Massberg S, Zinkernagel RM, Hengartner H, Busch DH. A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol 2011;12:1194-201.

10. Knabel M, Franz TJ, Schiemann M, Wulf A, Villmow B, Schmidt B, Bernhard H, Wagner H, Busch DH. Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nat Med 2002;8:631-7.