Prof. Dr. med. Wolfgang Kastenmüller

Institut für Systemimmunologie

Julius-Maximilians-Universität Würzburg
Versbacher Str. 9
97078 Würzburg
Phone: +49-931-31-81816
E-Mail: wolfgang.kastenmueller@uni-wuerzburg.de

University training and degree

2002 – 2008 M.D. (summa cum laude) in Medicine (2003), Technical University Munich. mentor: Prof. H. Bernhard.
1995 – 2002 Studies in Medicine, Universities of Regensburg and TU Munich

Advanced academic qualifications

2008 Specialization in Microbiology, Virology and Epidemiology of Infectious, Board Certification (2008)

Postgraduate professional career

Since 09/2017 Full Professor and Chair of Institute of Systems Immunology I,
University Würzburg
2013 – 2017
Associate Professor University Bonn
2008 – 2012
Post-doc, NIAID, National Institutes of Health, USA, Ronald N. Germain
2003 – 2008
Physician Scientist, Technical University Munich

2019 ERC consolidator grant
2018
Max-Planck Research Group
2012
NRW-Rückkehrer Program
2012 
NIH Cytokine Interest Group: Best Paper award
2009
DFG Fellowship
2003
Dissertation award – Dietmar-Zumpf-Promotions Preis

a) Articles published by outlets with scientific quality assurance, book publications and works accepted for publication, but not yet published

1. Ataide MA, Komander K, Knöpper K, Peters AE, Wu H, Eickhoff S, Gogishvili T, Weber J, Grafen A, Kallies A, Garbi N, Einsele H, Hudecek M, Gasteiger G, Hölzel M , Vaeth M and Kastenmuller W. BATF3 programs CD8 T cell memory. Nat Immunol. 2020 Nov;21(11):1397-1407.

2. Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmuller W. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun. 2018 Nov 15;9(1):4805.

3. Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN and Kastenmuller W. CD8+ T cells orchestrate pDC – XCR1+ dendritic cell spatial and functional cooperativity to optimize priming. Immunity 2017 Feb 21;46(2):205-219

4. Eickhoff S, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmuller W. 2015. Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions. Cell 2015 Sep 10;162(6):1322-37.

5. Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmuller W, Latz E. 2014. The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation. Nat Immunol 15: 727-37

6. Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Homig-Holzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Forster I, Kastenmuller W, Kolanus W, Holzel M, Gaffal E, Tuting T. 2014. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 507: 109-13

7. Lammermann T, Afonso PV, Angermann BR, Wang JM, Kastenmuller W, Parent CA, Germain RN. 2013. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498: 371-5

8. Kastenmuller W, Brandes M, Wang Z, Herz J, Egen JG, Germain RN. 2013. Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. Immunity 38: 502-13

9. Kastenmuller W, Torabi-Parizi P, Subramanian N, Lammermann T, Germain RN. 2012. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 150: 1235-48

10. Gerner MY, Kastenmuller W, Ifrim I, Kabat J, Germain RN. 2012. Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes. Immunity 37: 364-76